I'm not very sure about what a Whale's comment will do to your reputation but I'm a witness to what a whale's upvote does.
When my reputation was 41.7, I did a post that got me a 100% upvote from @infovore and my reputation shot up to 43.1.
I was astonished and elated of course because the vote worth about $2.5 right there.
Also there's another whale @chbartist who's posts I always enjoy and follow because of the quality of his content, I think you should follow him too. I comment constructively and he regularly upvotes meaningful comments. It also helps my reputation grow rather quickly.
After just one month plus on Steemit, my reputation is at 45.
Interacting with Whales on a regular basis will definitely help with your reputation.