Yes, the effect of exercise on health may differ depending on the time of day it is performed. So the effect of exercise performed in the morning differs from the effect of exercise performed in the evening.
There is a significant difference between the effect of exercise performed in the morning and evening, and these differences are probably controlled by the body's circadian clock. Morning exercise initiates gene programs in the muscle cells, making them more effective and better capable of metabolising sugar and fat. Evening exercise, on the other hand, increases whole-body energy expenditure for an extended period of time. But morning exercise Is not necessarily better than evening exercise.
Generally, the transcriptional response and effects on the metabolites are stronger, following exercise in the morning and that this is likely to be controlled by a central mechanism involving the protein HIF1-alfa, which directly regulates the body's circadian clock.
Morning exercise increases the ability of muscle cells to metabolise sugar and fat. On the other hand, the exercise in the evening increases energy expenditure in the hours after exercise. Therefore, it cannot necessarily be concluded that exercise in the morning is better than an exercise in the evening. But it can be concluded that the effects of the two appear to differ.